Unique photoaffinity probes to study TGFß signaling and receptor fates.

A novel synthetic approach is used to prepare a diverse set of "first-in-class" dihydropyridine-based TGFß receptor degraders bearing photoaffinity labels. These probes serve as valuable tools to study TGFß receptor fates and dynamics - an important challenge in chemical biology.

[Sodium cromoglycate eyewash in allergic conjunctivitis. Multicentric controlled double-blind study. Review of the literature]. / Cromoglycate de sodium en collyre dans les conjonctivites allergiques. Etude contrôlée multicentrique à double insu. Revue de la littérature.

A randomized double-blind trial was conducted in 143 out-patients with allergic conjunctivitis (281 eyes). Active sodium cromoglycate collyre was compared with placebo in parallel groups over a four-week period. Highly significant advantage for active drug was demonstrated for subjective and objective symptoms as well as for overall assessment by patients and physicians. Results were compared with international data concerning this well-known anti-allergic compound.